Dystroglycan ligand with other proteins is essential. Glycosylation of dystroglycan is necessary for its ligand binding activity. Mutations in glycosyltransferase enzymes cause abnormal glycosylation of dystroglycan. This hypoglycosylation is associated with less binding with other proteins and causes some congenital muscular dystrophy. Pikachurin is the most recently identified dystroglycan ligand protein and is localized in the synaptic cleft in the photoreceptor ribbon synapse. The binding between dystroglycan and pikachurin requires divalent cations. Ca2+ produces strongest binding; Mn2+ produces only faint bindings and no binding with Mg2+ alone. Dystroglycan has different domains that allow multiple Ca2+ sites to form a stable pikachurin-dystroglycan connection. This shows that pikachurin can form oligomeric structures; and suggests the possibility of clustering effects can be important in modulating pikachurin-dystroglycan interactions. Another thing to be considered is that the presence of NaCl (0. 5M) strongly inhibits interaction between DG and other ligand proteins but has a modest inhibitory effect with pikachurin-DG ligand. This shows that there are differences between the binding of pikachurin-DG binding and DG binding with other proteins. Pikachurin seems to have more domains to bind with DG than other proteins. For example, experiments in ligand competition shows that presence of pikachurin inhibits laminin-111 binding with DG, but high concentrations of laminin-111 do not inhibit pikachurin binding to DG.

pikachurin funny pikachu name fact

Pikachurin links photoreceptors to bipolar cells (Image credits ...

What is Pikachurin? | Gnoggin - YouTube

... protein named after the Pokémon character Pikachu. Pikachurin is a

SciSeek - Web -...

... protein named after the Pokémon character Pikachu. Pikachurin is a

Pikachurin, I Choose You! – Scientific Scribbles

Figure 1 - Pikachurin is necessary for the apposition of photoreceptor ...

Pikachurin & a Charmander story | Systems United Navy

top part of pikachurin photoreceptor cells lower part of pikachurin

Pikachurin - Wikipedia

088: Pikachurin by NachtBeirmann on DeviantArt

harmann said so who googled pikachurin after watching this ep p yup

Pikachurin & a Charmander story | Systems United Navy

Pikachurin is an extracellular matrix-like retinal protein first ...

Figure 6 : Pikachurin, a dystroglycan ligand, is essential for ...

Dystroglycans (Dystroglycan)

Figure 1 : Pikachurin, a dystroglycan ligand, is essential for ...

Dystroglycans (Dystroglycan)

Figure 2 - Pikachurin localizes to the synaptic cleft of photoreceptor ...

Pikachurin ( Yuyushiki Episode 7)

Figure 3 - Generation of Pikachurin null mouse by targeted gene ...

Pikachurin | Did You Know | Pinterest

Did You Know…? | uwilllovebiochem

Did You Know Gaming? — Pokemon.

Ghetsis Used Hax! by pikachurin - Meme Center

... # rabbit # mouse # camera # pikachurin # pikachu photo 43 notes

Figure 4 - Pikachurin is required for proper apposition of bipolar ...

Pikachurin is a thing. What a time to be alive. | Pokémon | Know Your ...

pikachurin | Tumblr

Osmosis jones and his friend by DrPepperlove on DeviantArt

Pokemon Trading Card Game – DeadPark

Pikachu and Meowth have a classic Cat-and-Mouse Relationship

... chan and hatsuzuki (kantai collection) drawn by pikachurin - Danbooru

Image - Mag Mell - Dango Daikazoku Album Cover.jpg - Clannad Wiki ...

Pikachurin - Wikipedia

The "Science" of Pokemon Proteins: Pikachurin | Pokémon Amino

Pikachurin - Sinirbilim


Cobblestone Lissencephaly; Cobblestone Complex ...

28 datos curiosos que tienes que saber de Pokémon – eju.tv

EL BLOG DE PIKACHURIN: diciembre 2012

curiosidades de todo el mundo -OTAKU-

File:Coat of arms of Vietnam.svg | Cyber Nations Wiki ...

Stem Cell–Derived Photoreceptor Transplants Differentially ...

Saturday/ it’s Bumbershoot – Willem's Planet

10 choses que vous ne saviez pas sur Pikachu

10 Chemical Compounds With Weird Names

Anticuerpos Monoclonales y Policlonales | Wako América Latina

20 Fakta Menarik Tentang Pikachu ~ Otaku Indonesia

Los mejores records de los videojuegos [Mega lista] - O ...

Chuck Norris humilha Van Damme em nova paródia especial de ...

Accueil - Yann Bidon